Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran

A 28-year-old man with skin lesions all over his face visited a dermatologist clinic. He has no unusual medical history. Upon inspection, his forehead and right cheek revealed several distinct, erythematous plaques with scale. Nearby observation also revealed peripheral active inflammation, cerebral atrophy, and hyperpigmentation results of the pathological investigation, which showed hyperkeratosis, follicular plugging, and infiltration of mononuclear cells along the dermoepidermal interface, supported the discoid lupus erythematosus diagnosis. At 12:25, the antinuclear antibody (ANA) titer was negative. The combination of topical corticosteroids and sun protection measures produced a satisfactory clinical response.Up to 25% of patients with systemic lupus (SLE) develop uncoid lupus erythematosus, however it can also happen without other clinical signs of SLE.

Up to 25% of people with systemic lupus (SLE) develop uncoid lupus erythematosus, but it can also happen without other SLE-related clinical symptoms and in people with negative or low-titer ANA results. A patient's chance of getting SLE is between 5–10% in those with pure discoid lupus erythematosus. 3 There is a correlation between the quantity and size of discoid lesions and the likelihood of getting SLE in the future, which typically has moderate symptoms.

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2. Provost TT. The relationship between discoid and systemic lupus erythematosus. Arch Dermatol. 1994;130:1308.

3. Healy E, Kieran E, Rogers S. Cutaneous lupus erythematosus – a study of clinical and laboratory prognostic factors in 65 patients. Ir J Med Sci. 1995;164:113.

4. Callen JP. Systemic lupus erythematosus in patients with chronic cutaneous (discoid) lupus erythematosus. Clinical and laboratory findings in seventeen patients. J Am Acad Dermatol.1985;12:278.

Hassanzadeh Morteza .Uncoid lupus erythematosus. Insights of Clinical and Medical Images 2022.